| 1:05 PM | Mariners | Indians | J Saunders | Z McAllister | Progressive Field
Cleveland, Ohio |
| 1:05 PM | Blue Jays | Yankees | B Morrow | D Phelps | Yankee Stadium
Bronx, New York |
| 1:05 PM | Mets | Cubs | J Hefner | S Feldman | Wrigley Field
Chicago, Illinois |
| 4:05 PM | Rays | Orioles | R Hernandez | J Jurrjens | Oriole Park at Camden Yards
Baltimore, Maryland |
| 4:05 PM | White Sox | Angels | H Santiago | J Blanton | Angel Stadium of Anaheim
Anaheim, California |
| 4:05 PM | Reds | Phillies | B Arroyo | K Kendrick | Citizens Bank Park
Philadelphia, Pennsylvania |
| 7:05 PM | Astros | Pirates | E Bedard | A Burnett | PNC Park
Pittsburgh, Pennsylvania |
| 7:10 PM | Red Sox | Twins | R Dempster | S Diamond | Target Field
Minneapolis, Minnesota |
| 7:10 PM | Diamondbacks | Marlins | B McCarthy | T Koehler | Marlins Park
Miami, Florida |
| 7:10 PM | Dodgers | Braves | C Capuano | K Medlen | Turner Field
Atlanta, Georgia |
| 7:15 PM | Brewers | Cardinals | M Estrada | L Lynn | Busch Stadium
St. Louis, Missouri |
| 8:05 PM | Tigers | Rangers | A Sanchez | J Grimm | Rangers Ballpark in Arlington
Arlington, Texas |
| 8:10 PM | Giants | Rockies | T Lincecum | T Chatwood | Coors Field
Denver, Colorado |
| 8:40 PM | Nationals | Padres | J Zimmermann | E Stults | PETCO Park
San Diego, California |
| 9:05 PM | Royals | Athletics | E Santana | T Milone | O.co Coliseum
Oakland, California |
